CryoSafe is a modular dual-container cold-chain shipping system built from targeted reusable and biodegradable components. Material and ergonomic cues ensure reliable temperature control, prevent sample breakage and contamination, and significantly reduce environmental impact. CryoSafe accommodates varying community needs and sample volumes while promoting the use of standardized NWSS data collection processes nationwide, providing the infrastructure to detect and respond to disease outbreaks at scale.